Berberine verses Sorafenib for the treatment of Hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Sorafenib for the treatment of unresectable hepatocellular carcinoma
Raf kinases and vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases are potential molecular targets for obtaining both anti-tumor cell progression and anti-angiogenesis effects in cancers, including hepatocellular carcinoma (HCC). Sorafenib is an oral multi-kinase inhibitor that mainly targets Raf kinases and receptor tyrosine...
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Purpose. To describe the U.S. Food and Drug Administration (FDA) review and approval of sorafenib (Nexavar ; Bayer Pharmaceuticals Corp., Montville, NJ, and Onyx Pharmaceuticals Corp., Emeryville, CA), an oral kinase inhibitor, for the treatment of patients with unresectable hepatocellular carcinoma (HCC). Experimental Design. The FDA independently analyzed an international, double-blind, place...
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Hepatocellular carcinoma (HCC) is the fi fth most common malignancy worldwide with approximately 500,000 new cases per year, ranking as the third cause of cancer deaths. Until the very recent past no systemic therapy was available for patients with advanced HCC. However, advances achieved in the understanding of the molecular cancer biology and the subsequent introduction of molecularly targete...
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UNLABELLED Hepatocellular carcinoma has an increasing incidence and an impressive mortality. At present, the only authorized systemic treatment is the multi-kinase inhibitor sorafenib. A multitude of clinical trials are aimed at improving outcomes, both in firstY- and in second-line therapy. In this multitude of clinical trials, the purpose of our article was to familiarize physicians with the ...
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ژورنال
عنوان ژورنال: International Journal of Biomedical Investigation
سال: 2020
ISSN: 2581-4745
DOI: 10.31531/2581-4745.1000125